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Joke of the Day: 29-01-2010
Published: Jan 29, 2010 - 08:06 PM
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"He's gone to Rome, to blow that candle out" came the harried reply.
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New Chitinase Inhibitors Effective imitation: chitinase inhibition by chitobiose and chitotriose thiazolines. Image: Di- and trisaccharide analogues of the oxazoline intermediate formed during enzymatic hydrolysis of chitin were found to be potent inhibitors of chitinase A. The high affinity and enzymatic stability of a readily synthesized thioamide trisaccharide (two molecules of which are shown in the enzyme active site), and the mechanism-based mode of inhibition, make this analogue a promising candidate for broad-spectrum chitinase inhibition. [Credit: Angewandte Chemie, Wiley-VCH] |
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